United Kingdom – IndieBio – #1 in Early Stage Biotech https://indiebio.co #1 in Early Stage Biotech Tue, 29 Apr 2025 13:12:56 +0000 en-US hourly 1 https://wordpress.org/?v=6.7.2 https://indiebio.co/wp-content/uploads/2025/04/cropped-cropped-indie-bio-logo-512-32x32.png United Kingdom – IndieBio – #1 in Early Stage Biotech https://indiebio.co 32 32 Spintex https://indiebio.co/company/spintex/ Fri, 11 Apr 2025 22:08:35 +0000 http://localhost:10023/company/spintex/ Spider silk is renown for being one of the strongest materials on the planet. Light as a feather but stronger than steel (by weight). Scientists have been to make artificial silk for a long time, but have failed to produce them at scale and in industrially amenable conditions.

Spintex has invented an entirely new, scalable method of making silk, using a naturally derived protein. Their critical insight is that, when it comes to spiders, how they spin fibers is as critical, or even more so, as the proteins they use. By mimicking spider spinning, and using a natural protein, Spintex is already surpassing premium silk in performance, with no compromise on look and feel. They’re starting with the textiles industry and will eventually move towards high-value medical applications.

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Sequential Skin https://indiebio.co/company/sequential-skin/ Fri, 11 Apr 2025 22:08:35 +0000 http://localhost:10023/company/sequential-skin/ Sequential Skin provides the world’s first truly personalized skincare solution. Their easy-to-use at-home test kit uses advanced genetic sequencing technology to understand how your genes, skin microbiome, and environment interact to define the unique needs of your skin. They then match you to tailored skin care products that provide the exact ingredients that will work best for your skin, to boost your overall health.

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Multus Media https://indiebio.co/company/multus-media/ Fri, 11 Apr 2025 22:08:23 +0000 http://localhost:10023/company/multus-media/ Multus Media develops the key ingredient to make cultivated meat affordable and profitable. Livestock agriculture contributes to 15% of all greenhouse gas emission globally which is more than the entire transportation sector combined. Cultivated meat brings an 87% reduction in CO2 equivalent emissions, along with 96% less freshwater use and 99% less land use to produce the same amount of meat. ​

This is why our mission is to design growth media that provides a collective benefit to the whole industry by lowering entry barriers, shortening routes to market, and supporting scale. Multus Media is accelerating the forefront of an industry that will replace the devastating impacts of livestock agriculture.

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P.Happi https://indiebio.co/company/brightcure-ltd/ Fri, 11 Apr 2025 22:07:57 +0000 http://localhost:10023/company/phappi/ P.Happi’s bioactive ingredient continuously protects, restores and balances your intimate skin. Our products calm your urogenital area which can be irritated and damaged by antibiotic therapies and harmful bacteria living in your gut and colonizing women’s intimate area. Unhealthy food, irritation, and changes in pH lead to reduced urogenital comfort making it easier for bad bacteria to grow on your skin.

P.Happi’s ACTIVE COMPONENT kills the harmful bacteria and activates the skin’s natural ability to repair and protect itself, thereby boosting your natural immune system to promote a healthy woman’s intimate microbiome.

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Alora https://indiebio.co/company/alora/ Fri, 11 Apr 2025 22:07:50 +0000 http://localhost:10023/company/alora/ The world’s food demands are expected to almost double by 2050, at the same time when climate change is stealing our supply our arable land for crop production, and a dearth of fresh water for both human and agricultural uses. Alora confronts these challenges by expanding our imagination, to think beyond these resources as the only way to grow crops.

Alora removes land and freshwater as agricultural constraints, by helping crops that are normally grown on land to grow in the ocean. By removing land and freshwater as key constraints they can grow crops 20X cheaper than on land. The scientific insight came from mangroves and seagrasses that have genes that are highly efficient in managing salt. Alora’s first crop is rice, a crop that feeds over half the world’s population, but is also a notorious methane producer because of the soil bacteria. By growing rice in floating ocean paddies, they will be able to provide food security to the world while also offsetting CO2 emissions

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BugBiome https://indiebio.co/company/bugbiome/ Tue, 25 Feb 2025 20:30:03 +0000 http://localhost:10023/company/bugbiome/ Every year, pests destroy 20% to 40% of global crop yields despite widespread use of synthetic pesticides. We spend $100 billion per year on chemicals that perform poorly, kill pollinators, and have been correlated with cancer, endocrine disruption, and brain damage in human beings. Farmers will need better solutions to feed 9.7 billion people in 2050, up from 8 billion today.

BugBiome harnesses nature’s own defenses to protect crops from pests without any harm to people or pollinators. The team sources bioprotectants from the microbiomes of plants that have evolved to eliminate the target pest. BugBiome then uses a specialized consortia of microbes to camouflage the bioprotectant, luring in pests while minimizing their ability to develop resistance.

BugBiome’s key advantage is AvidX, a high-throughput screening platform that observes multiple aspects of insect behavior to identify microbes with diverse modes of protecting crops. These include feeding deterrents, egg-laying inhibitors, and toxins, which can be combined to mimic the microbial communities that thwart pests in nature. BugBiome aims for AvidX to be significantly faster and more cost-effective than existing screening methods, which examine one behavior and microbe at a time in conditions unrepresentative of a real farm.

BugBiome was co-founded by Dr. Alicia Showering, PhD in molecular microbiology for disease control, and Christopher Mosedale, an entrepreneur specializing in biotech commercialization. They aim to first produce an evidence-backed bioprotectant against aphids, a global threat to food security through the plant viruses they transmit. Ultimately, BugBiome’s technology might have an answer for every plant pest that harms humanity.

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Nukoko https://indiebio.co/company/nukoko/ Tue, 25 Feb 2025 20:29:56 +0000 http://localhost:10023/company/nukoko/ For centuries, chocolate has been a staple ingredient and sweet treat in diets all over the world, but its future is in trouble. Chocolate production has long been associated with significant carbon emissions and deforestation, with a looming supply deficit predicted by 2030. To save chocolate, Nukoko is transforming the industry with its sustainable and healthy range of cocoa-free chocolate products. Their innovative solution uses precision fermentation to recreate chocolate flavors without relying on increasingly rare cocoa beans, making them the first ‘bean to bar’ maker to utilize this cutting-edge technology. With their proprietary platform, Nukoko can create chocolate using locally sourced beans from temperate regions.

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NANOPLUME https://indiebio.co/company/nanoplume/ Tue, 25 Feb 2025 20:29:41 +0000 http://localhost:10023/company/nanoplume/ The world depends on insulation that wastes up to 60% of heating and cooling energy, is heavy and bulky, and is 80% derived from petrochemicals. There’s been little innovation in this $65 billion industry, which still sells thick glass, sand, and plastic composites invented nearly a century ago. Aerogels—the lightest, thinnest, and best insulating materials known—could disrupt the insulation market. But so far, they’re too expensive and fragile for anything but niche uses.

Enter NANOPLUME which has developed a bio-based aerogel that is strong enough for the built environment and three times more insulating than mineral wool and fiberglass insulation. NANOPLUME upcycles widely available biowastes and uses conventional industrial equipment to produce this aerogel. The resulting insulation is affordable, biodegradable, dust- and mold-free, fire-retardant, and composed of 99% air.

Currently, a large housing manufacturer is testing NANOPLUME’s aerogel as a thermal break material for the floors, windows, and doors in timber-frame homes. Installed throughout structures, aerogels could enable builders to use less load-bearing material, excavate less dirt, and build more housing per hectare of land. This could increase profit margins for builders while reducing heating and cooling costs for homeowners.


NANOPLUME was founded by Theresa Hoffmann, a deep tech venture developer, and Chemical Engineers Tara Love, PhD, and Tafadzwa Motsi, PhD and MBA. The team has significant experience developing and commercializing bio-materials. They aim to improve energy efficiency, space efficiency, and circularity across many industries by introducing a long-overdue advance in insulation technology.

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Bactery https://indiebio.co/company/bactery/ Tue, 25 Feb 2025 20:29:41 +0000 http://localhost:10023/company/bactery/ The $10 billion precision agriculture industry is struggling to power the millions of sensors it needs to improve crop yields, reduce costs, and support food security amidst climate change. Farms are usually remote and lacking in energy infrastructure, but sensors reliant on single-use batteries or solar systems are prohibitively expensive because they require maintenance. Someone has to replace dead batteries and clean dust off the solar panels.

UK-based Bactery has developed a battery system that draws electricity from natural bacteria as they break down organics in agricultural soils, releasing electrons. In one year, a single Bactery can generate the amount of energy stored in ten AA batteries—double what a typical sensor requires. The low-profile device sits submerged almost entirely underground, safely out of the way, and requires no additional infrastructure or maintenance. Bactery calculates that its units, built to work for over 25 years, are 5,000 times less expensive than solar units over their lifetimes. And like solar, they generate zero carbon emissions during use.

Drs. Jakub Dziegielowski, Mirella Di Lorenzo, and Benjamin Metcalfe, co-founders of Bactery, have collaborated at the University of Bath for over five years and are considered the world’s top researchers in soil electricity generation. They’ve shown that a Bactery could, eventually, produce up to 4 watts per square meter of soil, promising a future where one-quarter of an average U.S. lot can power an entire home.

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CroBio https://indiebio.co/company/crobio/ Tue, 25 Feb 2025 20:29:37 +0000 http://localhost:10023/company/crobio/ In discussions surrounding climate change, there is often a focus on the negative impacts of high carbon levels in the atmosphere. However, it’s important to recognize that carbon itself is not our adversary. Instead, CroBio is leading the charge against years of unsustainable practices by restoring the balance of carbon between the soil and the atmosphere. With their innovative technology, they introduce cellulose-producing bacteria directly to plant roots. This process boosts carbon levels in the soil while also increasing water retention by more than 20X. By harnessing the power of the carbon cycle, CroBio’s advanced biotech solution enables the large-scale capture and sequestration of carbon emissions. This approach not only revitalizes soil health but also fosters biodiversity, improves food security, and paves the way for a more sustainable future for everyone.

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