Pre-Seed – IndieBio – #1 in Early Stage Biotech https://indiebio.co #1 in Early Stage Biotech Tue, 29 Apr 2025 10:45:58 +0000 en-US hourly 1 https://wordpress.org/?v=6.7.2 https://indiebio.co/wp-content/uploads/2025/04/cropped-cropped-indie-bio-logo-512-32x32.png Pre-Seed – IndieBio – #1 in Early Stage Biotech https://indiebio.co 32 32 mFluiDX https://indiebio.co/company/mfluidx/ Fri, 11 Apr 2025 22:09:18 +0000 http://localhost:10023/company/mfluidx/ Three years before COVID made everyone care about rapid molecular diagnostics, mFluiDx was already working on it. They were fighting epidemics before it was cool. Their initial prototype, funded by The Gates Foundation and DARPA, was working on rapid diagnostics for Zika virus. When patients would normally have to wait for days to get a result. mFluiDx’s prototype offered them an accurate diagnosis faster than a Spanish siesta, and 100X cheaper than a PCR setup.

mFluiDx presents a fast and portal DNA-based technology for identifyuing outbreaks of dangerous diseases in the field. Using microfluidics, they’ve engineered a field-ready, affordable, sensitive, and rapid approach that democratizes high-need diagnostics for everyone in the world.

mFluiDx selected as one of the top 20 startups to pitch at TechCrunch Startup Battlefield, from a pool of 900 startups globally.

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Dahlia Biosciences https://indiebio.co/company/dahlia-biosciences/ Fri, 11 Apr 2025 22:09:15 +0000 http://localhost:10023/company/dahlia-biosciences/ Dahlia Biosciences is leading the development of cell-based RNA detection tools using CRISPR technology. The foundational RNA-targeting Cas9 technology was invented by Dr. Mitchell O’Connell and Dr. Sam Sternberg in the laboratory of Dr. Jennifer Doudna at UC Berkeley.

The company is dedicated to empower scientists to study and isolate cells at high resolution via sensitive, robust, and multiplexed RNA detection in both fixed and live cells. Their CRISPR based RNA detection reagents will plug seamlessly into existing flow cytometry workflows, reducing the time and cost-basis of research and development. Their kits and reagents can supercharge the many applicaitons based on fixed-cell analysis and live-cell sorting with wide-ranging implications for detection of disease to design of biomarkers and drugs.

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Ardra Bio https://indiebio.co/company/ardra-bio/ Fri, 11 Apr 2025 22:09:12 +0000 http://localhost:10023/company/ardra-bio/ “Natural ingredients is the fastest growing segment in food, personal care, and health-&-wellness industry, but large companies can’t find reliable scalable supplies. For example, in 2016 there was an acute shortage of natural citrus ingredients because of citrus greening disease. Just the year before, prices of natural vanilla increased 10X due to low supply and increased demand.

Ardra’s synthetic biology platform unlocks multiple hard to make high value compounds through the fermentation of natural sugars, and their expertise in making designer microorganisms. Their platform utilizes computational methods in conjunction with a high throughput screening of proprietary enzyme libaries. This platform has already ben validated for multiple ingredients. Ardra has one joint development agreement to scale and distribute their first fragrance, leaf aldehyde. Deeper in their pipeline is animal-free Heme, Hazelnut flavor, a ketone mono-ester, cannabinoids, and several natural colors.

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Amino Labs https://indiebio.co/company/amino-labs/ Fri, 11 Apr 2025 22:09:11 +0000 http://localhost:10023/company/amino-labs/ Amino Labs is pioneering accessible genetic engineering by enabling non-experts to begin learning and doing genetic engineering projects outside of traditional environments. With a technology ecosystem that includes a new type of lab equipment called a minilab, a wide range of genetic engineering wetware kits, and online software simulations, Amino Labs offers the most comprehensive range of genetic engineering education products on the market.

Amino Labs is unique in that it is the only company that tailors products for non-experts. Presently there are educational products that aid in teaching genetic engineering, however, they are designed and developed for “expert” teachers that have professional training (life science Ph.D or industry expertise), and for schools with traditional laboratory equipment. This represents a substantial barrier and we estimate that more than 90% of secondary schools, more than 47,000 schools in North America, are unable to offer genetic engineering education to their students.

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Nuro Corp https://indiebio.co/company/nuro-corp/ Fri, 11 Apr 2025 22:09:03 +0000 http://localhost:10023/company/nuro-corp/ With the 17 million new patients every year who are recovering from a stroke, a third of them will be touchless and voiceless. These victims have aphasia and paralysis to a point that they can no longer interact with the rest of the world, and can bring an individual to a such an imprisonment in their own bodies, that life feels like it no longer matters.

Nuro is making a headset and multimodal, multidirectional operating system (dubbed NUOS) to help a locked-in patients communicate with the world. Their headset is combining EEG and EOG into a set of algorithms that give stroke patients their independence and dignity back. You can view their current work on their website where they show patients communicating independently with just their brain – no voice, no touch. They are the only manufacturer in the world cleared by Health Canada, US IRB and US FDA under ‘Expanded Access’ for Communication by Brain for up to Locked-In Stage VI ALS. NURO has developed a complete neurological product line named NUOS, which can be implemented instantly without any brain surgery and with a wide range of individuals, from healthy human beings to victims of Stroke, Trauma or Neurodegeneration.

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Neurocarrus Inc https://indiebio.co/company/neurocarrus-inc/ Fri, 11 Apr 2025 22:09:01 +0000 http://localhost:10023/company/neurocarrus-inc/ Traditionally, people in pain are given Opioids—which, although they relieve pain, can have dangerous side effects such as loss of motor function, and addiction. Ocycontin, Vicodin, and other pain relievers are effective in subduing pain, but they are extremely addictive, which causes major problems in families and communities.

The Opioid Crisis is a reality we’re facing now—but what if pain could be treated another way? That’s exactly what Neurocarrus has been working on. Their new drug delivery technology safely disrupts pain signals without possessing addiction-forming qualities. The company’s lead asset, N-001, is a novel protein that was synthesized to target key sensory neuron structures called actin. It is designed to disrupt peripheral pain signaling without affecting motor function or causing addiction.

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Michroma https://indiebio.co/company/michroma/ Fri, 11 Apr 2025 22:09:01 +0000 http://localhost:10023/company/michroma/ The vast majority of food dyes used today are synthetic chemicals derived from petroleum which have been linked to allergies, hyperactivity, and even cancer. Biocolorants do exist, but they are expensive to use and don’t hold their color when cooked or processed; insect-based dyes aren’t halal, vegan or kosher.

Michroma’s sustainable solution uses edible fungi cells that express the natural colorant into the bioreactor. No solvents are needed to extract and purify the color. The performance characteristics of their dyes are far superior to existing biocolorants.

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Lingrove https://indiebio.co/company/lingrove/ Fri, 11 Apr 2025 22:08:57 +0000 http://localhost:10023/company/lingrove/ Wood is a touchy subject. It could be considered a more sustainable material than plastic because it’s regenerative, but we’re simply just not regenerating them fast enough.

Lingrove is a materials company that is making wood without the trees. Their signature material, Ekoa, is lighter than carbon fiber, stiffer than fiberglass, and the wood grain finish is simply beautiful. Their product is made from a bioresin bonded with flax, which is normally discarded anyway after they are harvested for flaxseed. Ekoa can be molded into complex shapes and dyed to match the finishes of even the most expensive hardwoods. High performance, planet-positive and carbon-negative products without compromising the beauty.

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Convalesce Inc https://indiebio.co/company/convalesce-inc/ Fri, 11 Apr 2025 22:08:55 +0000 http://localhost:10023/company/convalesce-inc/ Convalesce is a biotech company pioneering local in situ genetic and cellular reprogramming, such as turning glial cells to neurons, or alpha to beta cells to replenish insulin. Reprogramming these cells ex-vivo has compromising limitations and nucleic acid medicines can’t effectively localize in vivo.

Convalesce have developed a platform that enables hyperlocal cell reprogramming through advanced materials harboring genes and/or cells of interest in vivo. We have demonstrated that CNV platform’s ECM can provide robust cell survival (3X) in vivo and enhance targeted differentiation. We were also able to get 2.5X higher expression of a gene-of-interest. Convalesce is leveraging its platform initially to target eye disease, dry age related macular degeneration (AMD) and is raising series seed to complete pre-clinical development by 2022.

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Dalton Bioanalytics https://indiebio.co/company/dalton-bioanalytics/ Fri, 11 Apr 2025 22:08:55 +0000 http://localhost:10023/company/dalton-bioanalytics/ Dalton Bioanalytics has developed a new way of analyzing all of the different types of biochemicals in blood. Using tried-and-true liquid chromatography mass spectrometry, they measure proteins, lipids, electrolytes, metabolites, and other small molecules–providing a more complete analysis at a fraction of the cost while maintaining data integration and integrity.

This data rich platform has applications for human health, from discovering novel biomarkers to developing new clinical tests to drug development. Our vision is to create a single low cost liquid biopsy that can be used for early detection across a wide range of common and rare diseases and conditions. Dalton is also working with many Fortune 500 companies to understand and develop better food and consumer goods, and optimize bioprocesses for industry.

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