Healthcare – IndieBio – #1 in Early Stage Biotech https://indiebio.co #1 in Early Stage Biotech Tue, 29 Apr 2025 10:45:58 +0000 en-US hourly 1 https://wordpress.org/?v=6.7.2 https://indiebio.co/wp-content/uploads/2025/04/cropped-cropped-indie-bio-logo-512-32x32.png Healthcare – IndieBio – #1 in Early Stage Biotech https://indiebio.co 32 32 mFluiDX https://indiebio.co/company/mfluidx/ Fri, 11 Apr 2025 22:09:18 +0000 http://localhost:10023/company/mfluidx/ Three years before COVID made everyone care about rapid molecular diagnostics, mFluiDx was already working on it. They were fighting epidemics before it was cool. Their initial prototype, funded by The Gates Foundation and DARPA, was working on rapid diagnostics for Zika virus. When patients would normally have to wait for days to get a result. mFluiDx’s prototype offered them an accurate diagnosis faster than a Spanish siesta, and 100X cheaper than a PCR setup.

mFluiDx presents a fast and portal DNA-based technology for identifyuing outbreaks of dangerous diseases in the field. Using microfluidics, they’ve engineered a field-ready, affordable, sensitive, and rapid approach that democratizes high-need diagnostics for everyone in the world.

mFluiDx selected as one of the top 20 startups to pitch at TechCrunch Startup Battlefield, from a pool of 900 startups globally.

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Dahlia Biosciences https://indiebio.co/company/dahlia-biosciences/ Fri, 11 Apr 2025 22:09:15 +0000 http://localhost:10023/company/dahlia-biosciences/ Dahlia Biosciences is leading the development of cell-based RNA detection tools using CRISPR technology. The foundational RNA-targeting Cas9 technology was invented by Dr. Mitchell O’Connell and Dr. Sam Sternberg in the laboratory of Dr. Jennifer Doudna at UC Berkeley.

The company is dedicated to empower scientists to study and isolate cells at high resolution via sensitive, robust, and multiplexed RNA detection in both fixed and live cells. Their CRISPR based RNA detection reagents will plug seamlessly into existing flow cytometry workflows, reducing the time and cost-basis of research and development. Their kits and reagents can supercharge the many applicaitons based on fixed-cell analysis and live-cell sorting with wide-ranging implications for detection of disease to design of biomarkers and drugs.

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BioAesthetics https://indiebio.co/company/bioaesthetics/ Fri, 11 Apr 2025 22:09:12 +0000 http://localhost:10023/company/bioaesthetics/ BioAesthetics’ Nipple-Areolar Complex Graft, or NACgraft, is a revolutionary next step in breast reconstruction that will provide patients who have had mastectomies with a new, natural, living nipple and areola. The NACgraft is a cell-free, biologically-derived nipple and areola graft that once applied by a surgeon, will allow the patient’s own body to integrate the NACgraft. This process uses the patient’s own natural ability to heal, resulting in a real and living nipple unique to and uniquely a part of the patient.

They are currently engaged in a clinical stufy for their NAC, and beginning development of enhanced biologically derived grafts — capable of sustained drug delivery — to improve outcomes for third degree burn survivors through an NIH grant.

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STÄMM https://indiebio.co/company/stamm/ Fri, 11 Apr 2025 22:09:09 +0000 http://localhost:10023/company/stamm/ Biology is the best platform for manufacturing cells. It can grow and produce all kinds of biomaterials very effectively. But for humans to be able to tap into this potential, we have to build bioreactors and figure out how to scale them in order to produce the massive amounts of biomaterials we need.

Bioreactors technology is very different when you’re optimizing for one reaction at one liter versus 100,000 liters, but this is where Stämm comes in. They are reinventing the way bioreactors work by developing a modular microfluidic platform that controls all the physical parameters, such as nutrients and dissolved oxygen, in a controlled environment. Unlike traditional bioreactor systems, their microfluidic bioreactor scales by adding more modules to increase the size of the reactor.

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Sun Genomics https://indiebio.co/company/sun-genomics/ Fri, 11 Apr 2025 22:09:09 +0000 http://localhost:10023/company/sun-genomics/ It all begins in the gut. We know that a balanced gut microbiome is key to a healthy (and happy) life. Probiotics, ingestible products that contain healthy bacteria and yeast, are available for people to buy and help with their digestive issues. But not all probiotics are created equal.

Sun Genomics found that an individual’s genome can help identify which probiotic strains are best for the person. By creating personalized probiotics, the company can eliminate the guesswork that’s involved with buying probiotics off the shelf and help people regain control of their health. Customers of all ages (babies, tots, adults) can get a whole genome sequencing of their gut microflora now, and get custom-tailored probiotics sent to their door right away, with the Floré product by Sun Genomics.

Sun Genomics has also launched a new academic collaboration focused on understanding the potential link between the gut microbiome and the Autism Spectrum Disorder

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CASPR Biotech https://indiebio.co/company/caspr-biotech/ Fri, 11 Apr 2025 22:09:05 +0000 http://localhost:10023/company/caspr-biotech/ What do you do when all the Cas proteins get locked up in IP because of the CRISPR war? You go to the ends of the earth to find an undiscovered Cas protein. And that’s what the Caspr team did, traveling to high-altitude mountains and volcanoes to find extremophiles in Argentina where there might be a Cas protein whose upbringing might endow them with temperature resistance.

Caspr has been acquired by a Fortune 100 company. Now Caspr is using their special Cas to develop cheap and rapid CRISPR-based test kits ƒor infectious diseases. One month after they graduated from IndieBio, COVID-19 hit and Caspr’s team knew exactly what they had to do. They flew out their scientists out of Argentina to come live in San Francisco, where 15 of them lived in a single house in Alamo Square, all trying to develop tests for the coronavirus.

After demonstrating how rapidly they were able to develop their tests, Caspr was approached by Amazon to help with their internal efforts to test their employees.

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Dalton Bioanalytics https://indiebio.co/company/dalton-bioanalytics/ Fri, 11 Apr 2025 22:08:55 +0000 http://localhost:10023/company/dalton-bioanalytics/ Dalton Bioanalytics has developed a new way of analyzing all of the different types of biochemicals in blood. Using tried-and-true liquid chromatography mass spectrometry, they measure proteins, lipids, electrolytes, metabolites, and other small molecules–providing a more complete analysis at a fraction of the cost while maintaining data integration and integrity.

This data rich platform has applications for human health, from discovering novel biomarkers to developing new clinical tests to drug development. Our vision is to create a single low cost liquid biopsy that can be used for early detection across a wide range of common and rare diseases and conditions. Dalton is also working with many Fortune 500 companies to understand and develop better food and consumer goods, and optimize bioprocesses for industry.

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Sequential Skin https://indiebio.co/company/sequential-skin/ Fri, 11 Apr 2025 22:08:35 +0000 http://localhost:10023/company/sequential-skin/ Sequential Skin provides the world’s first truly personalized skincare solution. Their easy-to-use at-home test kit uses advanced genetic sequencing technology to understand how your genes, skin microbiome, and environment interact to define the unique needs of your skin. They then match you to tailored skin care products that provide the exact ingredients that will work best for your skin, to boost your overall health.

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OncoPrecision https://indiebio.co/company/oncoprecision/ Fri, 11 Apr 2025 22:08:31 +0000 http://localhost:10023/company/oncoprecision/ OncoPrecision can predict a patient’s response to cancer therapies by replicating the tumor microenvironment ex vivo. Their unique, triple co-culture method increases patient-derived cancer cell viability 60x in a 2.5D format that has been validated using real patient data. For patients in dire need of the right cancer treatment the first time, OncoPrecision offers doctors the assurance that decisions made today will make the difference tomorrow.

When time is of the essence, being able to screen potential therapies with your personalized cancer avatar in under 10 days is fast. Doing so with more accuracy than today’s sequencing or organoid approaches is huge. Through their growing list of strategic partnerships, OncoPrecision is screening, selecting, and speeding up the delivery of precision oncology.

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Microgenesis https://indiebio.co/company/microgenesis/ Fri, 11 Apr 2025 22:08:21 +0000 http://localhost:10023/company/microgenesis/ Microgenesis has worked with some of the hardest infertility cases there are – women who have undergone and failed multiple rounds of IVF. With a cohort of 287 would-be mothers, over 75% of their patients became pregnant using their proprietary test and nutraceutical regimen. Microgenesis uses microRNA signatures, on swabs from the fertility biome, to diagnose 64 phenotypes. They treat patients with 53 combinations of probiotics, nutraceuticals and diet-change. With personalized nutraceuticals and probiotics it resets fertility in 90 days.

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